Protein Details: P2X purinoceptor 5

Protein ID

ICDB_Pro_1355

Protein Name

P2X purinoceptor 5

Gene Name

P2rx5

Organism

Mus musculus (Mouse)

Length

455 amino acids

AlphaFoldDB

AF-Q91VE2-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium. Unlike; other P2RX receptors; the P2X5 receptor is also permeable to chloride (By similarity). Acts as an important regulator of inflammatory-related bone loss and osteoclast multinucleation.

Sequence

MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEEDNVEVEANEMEQELPEDKPLERVHQDEQALELAQSGRKQNSNCQVLFEPARSGLQENAFVNMKPSQILQTVKT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 69..71; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 189; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 294..296; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 314; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"

Disease

Location

Expressed in a number of tissues; with highest levels detected in heart and kidney

DOI ID

10.1016/s0378-1119(01)00484-x; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1038/s41598-017-00139-2; 10.7554/elife.84796

RefSeq

NP_201578.2